Multicenter study in Cell reveals that specific gut bacterial metabolites either enhance or impair CAR-T cell therapy efficacy in cancer patients.
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Potent Neutralization and In Vivo Protection Against Measles Virus via Human Monoclonal Antibodies
Vanderbilt Health researchers isolate human monoclonal antibodies that potently neutralize measles virus replication in preclinical models.
Concordance Analysis of Minigene Assays and Patient RNA Informs Clinical Splicing Guidelines
Genome Medicine study establishes clinical recommendations for using construct-based RNA splicing assays to resolve uncertain genetic variants in inherited diseases
Simultaneous Multi-Receptor Adenosine Antagonism Reduces Scar Formation in Human Heart Models
Stanford researchers uncover a shared adenosine receptor signaling pathway that drives cardiac fibrosis and offer a novel target for anti-fibrotic therapies.
Transcriptional Pause Release and RNA Polymerase II Elongation Drive Atherosclerotic Plaque Instability
Leipzig University researchers show that targeting super elongation complex-driven gene transcription reduces endothelial transformation and stabilizes vulnerable atherosclerotic plaques.