A novel Nature Cell Biology study reveals that cancer cells hijack TEX264-mediated nucleophagy to clear trapped PARP1 and resist PARP inhibitor treatments.
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Regulatory IgA B-Cell Mobilization Drives Therapeutic Success in Anti-CD20 Depletion
A multiomic study reveals that anti-CD20 B-cell depletion therapies in multiple sclerosis work by recruiting protective, gut-derived IgA B cells into the bloodstream and brain.
High Temporal Stability of Adaptive Immune Signatures Amid Widespread Transcriptomic Fluctuation
A landmark longitudinal RNA-sequencing study shows that 85% of human blood genes vary more within a single individual over time than between different people.
Overlapping and Distinct Neural Pathways Underlying Human Placebo Analgesia
An international neuroimaging study of 409 participants reveals that placebo pain relief induced by verbal suggestion and classical conditioning relies on overlapping but distinct neural pathways.
Patient-Specific Carotid Artery-on-a-Chip Platform Maps Shear-Dependent Stroke Risk
A novel "physical twin" artery-on-a-chip platform replicates patient-specific carotid geometry to predict blood clot behavior and ischemic stroke risk beyond conventional stenosis measurements.