A multiomic study reveals that anti-CD20 B-cell depletion therapies in multiple sclerosis work by recruiting protective, gut-derived IgA B cells into the bloodstream and brain.
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High Temporal Stability of Adaptive Immune Signatures Amid Widespread Transcriptomic Fluctuation
A landmark longitudinal RNA-sequencing study shows that 85% of human blood genes vary more within a single individual over time than between different people.
Overlapping and Distinct Neural Pathways Underlying Human Placebo Analgesia
An international neuroimaging study of 409 participants reveals that placebo pain relief induced by verbal suggestion and classical conditioning relies on overlapping but distinct neural pathways.
Patient-Specific Carotid Artery-on-a-Chip Platform Maps Shear-Dependent Stroke Risk
A novel "physical twin" artery-on-a-chip platform replicates patient-specific carotid geometry to predict blood clot behavior and ischemic stroke risk beyond conventional stenosis measurements.
Mapping Long-Range Chromatin Interactions and Gene Control Mechanisms in Human Heart Failure
A ground-breaking single-cell study of over 750,000 heart cells maps how noncoding gene regulation breaks down during human heart failure progression.