New research shows that colorectal tumors bypass targeted therapies by activating an internal, non-genetic inflammatory alarm, which can be blocked to prevent drug resistance and relapse.
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Broad Spectrum Immunogenicity of Dual-Immunogen Formulations Against Segmented RNA Viruses
Immunologists have successfully mapped the human T cell genetic targets for Lassa fever, paving the way for a universal vaccine capable of preventing multiple deadly rodent-borne outbreaks.
Glucocorticoid Receptor Activation as a Driver of Myeloid-Derived Suppressor Cell Infiltration in Ovarian Cancer
Scientists have discovered that activating the glucocorticoid receptor in ovarian cancer cells drives immune evasion by attracting specialized suppressor cells that shield the tumor.
Electron Transport Chain Modulation of Dendritic Cells in the Tumor Microenvironment
Scientists have discovered that mitochondrial complex I acts as a metabolic switch in dendritic cells, controlling their ability to activate T cells against viruses and tumors.
Characterizing Right Atrial Phenotypic Shifts and Tissue Scarring in Persistent Atrial Fibrillation
Advanced proteomic mapping reveals that persistent atrial fibrillation damages the right atrium just as severely as the left, indicating a critical need for bi-atrial clinical therapies.