A comprehensive target trial emulation involving 2.5 million patients establishes that receiving same-day COVID-19 and influenza vaccinations does not increase the risk of serious adverse events.
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An Epigenetically Driven Mendelian Disorder Reveals Mechanistic Drivers of Age-Related Pathologies
Discovery of the rare genetic condition Heyn–Sproul–Jackson syndrome proves that DNA hypermethylation directly causes adult stem cell dysfunction and premature systemic aging.
Comparing Multimodal Self-Management, Spinal Manipulation, and Medical Care for Subacute Back Pain
A multi-center randomized clinical trial demonstrates that clinician-supported, tailored self-management programs are significantly more effective at preventing chronic low back pain than standard medical interventions.
Validation of an Electrocardiogram-Based Deep Learning Tool for Ventricular Arrhythmia Risk
A novel deep learning model utilizes widely available ECG waveform patterns to discover a new electrophysiological biomarker that significantly outperforms traditional screening for predicting sudden cardiac death.
Tracking Real-Time Audiovisual Attention Shifts in the Human Brain via Direct iEEG Modeling
Direct brain recordings from surgical patients reveal that the frontal cortex contains a structured spatial map that dynamically shifts focus between sight and sound to optimize real-time comprehension.