A Device study presents a UK CEiRSI risk-informed framework for validating in silico evidence in medical device regulatory submissions.
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SGLT2 Inhibition Reprograms Monocyte Metabolism to Attenuate Vascular Inflammation
A pilot study in Circulation demonstrates that empagliflozin directly reduces pro-inflammatory monocyte-platelet aggregates independent of weight loss.
Telomere Loss Predicts Increasing Comorbidity Burden in Pediatric and Adult Fontan Patients
A Journal of the American Heart Association study reveals that patients with Fontan circulation display shorter telomeres, indicating accelerated biological aging linked to adverse hemodynamics.
Cross-Compartment AI Model Improves Specificity in Detecting Heart Transplant Allograft Rejection
A JHLT Open study demonstrates that combining EKG data with blood biomarkers in a multi-modal AI model improves noninvasive cardiac transplant rejection detection.
Structural Basis of the Complex I to Complex II Transition in TNF Signaling via HERC4
Nature Structural and Molecular Biology study identifies HERC4 as the molecular switch converting RIPK1 to initiate TNF-induced cell death.