An 11-year JSCAI study reveals TAVR volume in patients under 70 increased nearly ninefold, expanding rapidly among individuals in their 60s.
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Targeting Hotspot PPP2R1A Mutations with Small-Molecule PP2A Activators Induces Tumor Regression
A Science Translational Medicine study shows molecular glue RPT04402 restores PP2A trimer assembly to drive tumor regression in high-grade uterine cancer.
Abdominal Obesity Outperforms BMI Category in Predicting Early-Onset Malignancies in Young Adult Cohort
An Annals of Internal Medicine study of 6.3 million adults links young-adult obesity and central adiposity directly to increased early-onset cancer risk.
Lancet Oncology Study Highlights Alternating TKI and Monoclonal Antibody Regimen for Untreated Clear Cell RCC
A Lancet Oncology phase 1/2 trial shows alternating pazopanib and bevacizumab extends median overall survival to 63.2 months in metastatic clear cell renal cell carcinoma.
Symptom-Level Network Clustering Outperforms Traditional Diagnostic Labels in Predicting Therapy Outcomes
A Psychological Medicine network analysis of 33,675 patients reveals symptom-level clusters predict distinct 12-week psychotherapy trajectories in anxiety and depression.
