A Science Translational Medicine study maps nearly one million single heart cells, uncovering distinct genetic and fibroblast-driven transcriptional programs across hypertrophic cardiomyopathy stages.
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Explainable AI Predicts Intramyocardial Hemorrhage Prior to Reperfusion in STEMI Patients
Advances study demonstrates that explainable AI predicts intramyocardial hemorrhage before reperfusion in STEMI patients, guiding real-time catheterization lab decisions.
Mitigating Polypharmacy Risks: Prioritizing Potentially Inappropriate Prescribing Cascades
A BMJ study identifies 24 common prescribing cascades where drug side effects are misdiagnosed, leading to unnecessary secondary prescriptions in older adults.
Mechanistic Insights Into Statin Chemoprevention Against MASLD-Associated Hepatocellular Carcinoma
A Hepatology Communications study reveals that statins inhibit YAP signaling in hepatic stellate cells by lowering GGPP, explaining potential chemopreventive effects against MASLD-related liver cancer.
Protein Delivery of ABE8e-V106W Base Editors Supports Human Embryo Viability
A Nature study reveals that human embryos efficiently repair base editor single-strand DNA damage, though off-target mosaicism currently prevents clinical germline application.