Article Impact Level: HIGH Data Quality: STRONG Summary of Clinical Cardiology, 46(11), 1371–1379. https://doi.org/10.1002/clc.24129 Dr. Wenxi Dang et al.
Points
- The study investigated the association between β2-adrenergic receptor autoantibody (β2-AA) levels and the presence of proximal left anterior descending (LAD) artery lesions in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).
- A cohort of 153 STEMI patients was enrolled, with higher levels of β2-AA observed in the proximal LAD group compared to the nonproximal LAD group.
- Multivariate logistic regression analysis revealed that high β2-AA levels were independently associated with proximal LAD lesions in STEMI patients.
- The study utilized a receiver operating characteristic curve to demonstrate the efficiency of β2-AA levels in detecting proximal LAD lesions, with the area under the curve (AUC) being 0.658.
- The findings suggest that STEMI patients with high β2-AA levels are more likely to have proximal LAD lesions, providing valuable insights for risk stratification and treatment strategies in this patient population.
Summary
The study aimed to investigate the association between β2-adrenergic receptor autoantibody (β2-AA) levels and the presence of proximal left anterior descending (LAD) artery lesions in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). A cohort of 153 STEMI patients was enrolled, with baseline characteristics compared between the proximal LAD group (n = 62) and the nonproximal LAD group (n = 91). The study collected admission serum to detect the levels of β2-AA and recorded echocardiogram data within 24 hours after PPCI and at the 6-month follow-up.
The findings revealed that the optical density values and positive rates of β2-AA in the proximal LAD group were significantly higher than those in the nonproximal LAD group (p < 0.05). Additionally, multivariate logistic regression analysis demonstrated that high β2-AA levels were independently associated with proximal LAD lesions in STEMI patients. Furthermore, the study utilized a receiver operating characteristic curve to illustrate the efficiency of β2-AA levels in detecting proximal LAD lesions, with the area under the curve (AUC) of the β2-AA optical density value being 0.658 (95% confidence interval 0.568−0.749; p = 0.001).
In conclusion, the study’s findings suggest that STEMI patients with high β2-AA levels are more likely to have proximal LAD lesions. This insight could inform risk stratification and treatment strategies for STEMI patients undergoing PPCI, providing valuable guidance for clinical decision-making and patient management.
Link to the article: https://onlinelibrary.wiley.com/doi/10.1002/clc.24129
References Dang, W., Cao, N., Zhang, Y., Li, W., & Li, H. (2023). Association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST‐segment elevation myocardial infarction. Clinical Cardiology, 46(11), 1371–1379. https://doi.org/10.1002/clc.24129
