Article Impact Level: HIGH Data Quality: STRONG Summary of Clinical Cardiology, 46(11), 1380–1389. https://doi.org/10.1002/clc.24103 Xinxin Ma et al.
Points
- Depression was found to play an intermediate role in the relationship between cardiovascular disease (CVD) and all-cause mortality, with a mediational percentage of 9.13%.
- The study, based on data from 33,156 adults extracted from the NHANES database, revealed that individuals with CVD had a significantly higher likelihood of experiencing depression.
- After adjusting for covariates, the association between CVD and depression was established, indicating a potential link between these two conditions.
- Subgroup analyses demonstrated that the mediating effect of depression on the association between CVD and all-cause mortality was consistent across different age groups, genders, and individuals with diabetes mellitus and dyslipidemia.
- The findings suggest that recognizing the intermediate effect of depression could aid clinicians in identifying high-risk populations early and provide valuable insights for disease management and mortality reduction strategies.
Summary
The study aimed to investigate the potential intermediate role of depression in the association between cardiovascular disease (CVD) and all-cause mortality. Utilizing demographic and clinical data from 33,156 adults (≥20 years old) extracted from the National Health and Nutrition Examination Survey (NHANES) database (2005−2018), the retrospective cohort study employed weighted univariate and multivariate COX regression analyses to explore the relationship between CVD and depression. The distribution-of-product method was utilized to assess the mediating effect of depression on the association between CVD and all-cause mortality, with evaluation indexes including odds ratios (ORs), hazard ratios (HRs), and 95% confidence intervals (CIs).
The findings revealed that among the participants, 11,514 had CVD, 5844 had depression, and 4759 died. After adjusting for covariates, CVD was associated with a high likelihood of depression (OR = 1.94), and depression played an intermediate role in the relationship between CVD and all-cause mortality (HR = 1.23) with a mediational percentage of 9.13%. Subgroup analyses further demonstrated the existence of this mediating effect across different age groups, genders, and individuals with diabetes mellitus (DM) and dyslipidemia.
In conclusion, the study’s findings suggest that depression may act as an intermediate factor in the association between CVD and all-cause mortality. This insight holds the potential for early identification of high-risk populations. It offers a valuable reference for disease management and mortality reduction, providing clinicians with a basis for targeted interventions to improve patient outcomes.
Link to the article: https://onlinelibrary.wiley.com/doi/10.1002/clc.24103
References Ma, X., Zhang, H., Tian, Y., Wang, Y., Liu, L., & Wang, L. (2023). Mediating effect of depression on the association between cardiovascular disease and the risk of all‐cause mortality: NHANES in 2005−2018. Clinical Cardiology, 46(11), 1380–1389. https://doi.org/10.1002/clc.24103
