Article Impact Level: HIGH Data Quality: STRONG Summary of Journal of the American College of Cardiology, 80(22), 2104–2115. https://doi.org/10.1016/j.jacc.2022.09.027 Dr. Neil Zakai et al
Points
- Plasma lipid concentrations pose a higher risk of coronary heart disease, considering that there are racial linkages of lipids with the onset of coronary heart disease.
- It is still unknown whether these new HDL measurements exhibit racial-specific relationships with cardiac problems and whether they can enhance risk assessment across all ethnic groups.
- Although it is impossible to rule out the findings, they reveal a race-specific effect and point to the necessity of racial group recommendations in cardiovascular prognosis. Continuous data input, including all racial and ethnic groups, is necessary for future attempts to calibrate and verify risk models.
Summary
This research was conducted to determine why Black individuals performed poorly in cardiac risk calculations.
The REGARDS study, which stands for Reasons for Geographic and Racial Differences in Stroke Cohort, enrolled 30,239 Black and White people under 45 years of age from the United States between 2003 and 2007. In order to calculate the racial group hazard of plasma cholesterol concentrations associated with the occurrence of cardiovascular heart disease, Cox regression methods adjusted for medical and etiquette risk variables were implemented.
During the follow-up period of 10 years, there were 664 and 951 cardiovascular events across Black and White people, respectively. Cholesterol and low-density lipoprotein levels were linked to a higher risk of coronary heart disease in both races.
Regarding gender-specific medical high-density lipoprotein cholesterol categories, bad cholesterol was associated with a higher probability of cardiac disorders in White adults but not Black adults. However, high-density lipoprotein cholesterol level was not linked to a reduction in Coronary heart disease in either race.
Triglycerides and low-density lipoprotein cholesterol only slightly influenced the risk of coronary heart disease in individuals of both races. In White adults, low HDL-C was linked with a higher risk of atherosclerosis, whereas high-density lipoprotein cholesterol level was not beneficial in any class. Appropriate risk estimations based on high-density lipoprotein cholesterol might result in incorrect risk assessment in Black individuals.
Though lethal Coronary heart disorders are more frequent in Black Americans than in White Americans, on average, the associated risk is lower in Black Americans. The American Heart Association, the U.S. Department of Health and Human Services, and the Institute of Medicine have addressed the need for research based on individuals to fill this information lack because despite differences by ethnicity in the prevalence of cardiovascular events risk factors and coronary heart disease consequences; limited information has been discovered about the precise causes of these discrepancies.
Link to the article: https://www.jacc.org/doi/10.1016/j.jacc.2022.09.027
References Zakai, N. A., Minnier, J., Safford, M. M., Koh, I., Irvin, M. R., Fazio, S., Cushman, M., Howard, V. J., & Pamir, N. (2022). Race-dependent association of high-density lipoprotein cholesterol levels with incident coronary artery disease. Journal of the American College of Cardiology, 80(22), 2104–2115. https://doi.org/10.1016/j.jacc.2022.09.027
