Article Impact Level: HIGH Data Quality: STRONG Summary of Clinical Cardiology, 46(11), 1326–1336. https://doi.org/10.1002/clc.24115 Dr. Panjaree Siwaponanan et al.
Points
- The study investigated small extracellular vesicle (sEV) levels and sEV-derived microRNA (miRNA) expression in atrial fibrillation (AF) patients with and without diabetes mellitus (DM).
- In AF patients with DM, a significant increase in total sEV levels and a decrease in sEV-miR-126 levels were observed.
- Multivariate logistic regression analysis revealed a positive association between total sEV levels and AF with DM and a negative association between sEV-miR-126 level and AF with DM.
- The combination of clinical data, total sEVs, and sEV-miR-126 level showed high discriminatory power for distinguishing AF from DM, outperforming analysis based on clinical data alone.
- Altered sEV levels and sEV-miR-126 may have implications for the pathophysiology and complications of AF with DM, offering potential as applied biomarkers for risk stratification and personalized management.
Summary
The study aimed to investigate the potential differences in small extracellular vesicle (sEV) levels and sEV-derived microRNA (miRNA) expression in atrial fibrillation (AF) patients with and without diabetes mellitus (DM). The researchers utilized nanoparticle tracking analysis and droplet digital polymerase chain reaction to compare sEV levels and sEV-miRNA expression in plasma samples from the two patient groups. The results revealed a significant increase in total sEV levels and a notable decrease in sEV-miR-126 levels in AF patients with DM. Multivariate logistic regression analysis further demonstrated a positive association between total sEV levels and AF with DM and a negative association between sEV-miR-126 level and AF with DM. Additionally, the combination of clinical data, total sEVs, and sEV-miR-126 level exhibited high discriminatory power for distinguishing AF from DM, surpassing the analysis based on clinical data alone. These findings underscore the potential of sEV-related biomarkers in enhancing this patient population’s understanding and clinical management.
The findings suggest that the altered levels of total sEV and sEV-miR-126 may have implications for the pathophysiology and complications of AF in the presence of DM, particularly related to endothelial dysfunction. These biomarkers hold promise for their potential role in distinguishing between AF patients with and without DM, offering valuable insights into the underlying mechanisms and clinical implications of AF in the context of diabetes mellitus. The study’s comprehensive analysis of sEV levels and sEV-miRNA expression in relation to AF and DM provides a foundation for further research into the development of applied biomarkers for risk stratification and personalized management of AF patients with comorbid diabetes.
The research underscores the significant potential of total sEV levels and sEV-miR-126 expression as biomarkers for distinguishing AF patients with and without DM. This study illuminates this comorbid condition’s pathophysiological mechanisms and clinical implications, providing crucial insights for risk assessment and personalized management strategies in AF patients with diabetes mellitus. The findings highlight the transformative potential of sEV-related biomarkers in enhancing this patient population’s understanding and clinical management.
Link to the article: https://onlinelibrary.wiley.com/doi/10.1002/clc.24115
References Siwaponanan, P., Kaewkumdee, P., Sudcharee, P., Udompunturak, S., Chomanee, N., Udol, K., Pattanapanyasat, K., & Krittayaphong, R. (2023). Increased small extracellular vesicle levels and decreased miR-126 levels associated with atrial fibrillation and coexisting diabetes mellitus. Clinical Cardiology, 46(11), 1326–1336. https://doi.org/10.1002/clc.24115
