Article Impact Level: HIGH Data Quality: STRONG Summary of European Heart Journal Open, 3(2), oead008. https://doi.org/10.1093/ehjopen/oead008 Dr. Shuai Yuan et al.
Points
- The study aimed to investigate the relationship between sleep duration and daytime napping with peripheral artery disease (PAD) risk.
- Observational analyses showed a U-shaped association between sleep duration and PAD risk, with short sleep [<5 h; hazard ratio (HR) 1.74; 95% confidence interval (CI) 1.31–2.31] or long sleep (≥8 h; HR 1.24; 95% CI 1.08–1.43) being associated with increased PAD risk.
- Positive associations were also found between daytime napping (HR 1.32, 95% CI 1.18–1.49) and PAD risk.
- Mendelian randomization (MR) analysis supported an inverse association between sleep duration and PAD risk, with an odds ratio (OR) per hour increase of 0.79 (95% CI, 0.55, 0.89) and an association between short sleep and increased PAD risk (OR 1.20, 95% CI, 1.04–1.38).
- The study concluded that short sleep duration was associated with an increased risk of PAD, suggesting that sleep may be an essential factor to consider in preventing and managing PAD.
Summary
This research paper investigated the association between sleep duration and daytime napping with peripheral artery disease (PAD) risk using observational and Mendelian randomization (MR) analyses. A cohort analysis was conducted among 53,416 Swedish adults. The results were replicated in a case-control study of 28,123 PAD cases and 128,459 controls from the veterans’ affairs Million Veteran Program (MVP) and a cohort study of 452,028 individuals from the UK Biobank study (UKB). The MR analysis was used for causal inference-based analyses of sleep-related traits and PAD using 31,307 PAD cases and 211,753 controls.
Observational analyses demonstrated a U-shaped association between sleep duration and PAD risk. In Swedish adults, incident PAD risk was higher in those with short sleep [<5 h; hazard ratio (HR) 1.74; 95% confidence interval (CI) 1.31–2.31] or long sleep (≥8 h; HR 1.24; 95% CI 1.08–1.43), compared to individuals with a sleep duration of 7 to <8 h/night. Positive associations were also found between daytime napping (HR 1.32, 95% CI 1.18–1.49) and PAD risk. The analyses in MVP and UKB supported the results.
MR analysis supported an inverse association between sleep duration and PAD risk, with an odds ratio (OR) per hour increase of 0.79 (95% CI, 0.55, 0.89) and an association between short sleep and increased PAD risk (OR 1.20, 95% CI, 1.04–1.38).
In conclusion, short sleep duration was associated with an increased risk of PAD. These findings suggest that sleep may be an essential factor to consider in preventing and managing PAD.
Link to the article: https://academic.oup.com/ehjopen/article/3/2/oead008/7068263
References Yuan, S., Levin, M. G., Titova, O. E., Chen, J., Sun, Y., Million Veteran Program, V. A., Åkesson, A., Li, X., Damrauer, S. M., & Larsson, S. C. (2023). Sleep duration, daytime napping, and risk of peripheral artery disease: Multinational cohort and Mendelian randomization studies. European Heart Journal Open, 3(2), oead008. https://doi.org/10.1093/ehjopen/oead008
