Article Impact Level: HIGH Data Quality: STRONG Summary of Clinical Cardiology, 46(7), 818–822. https://doi.org/10.1002/clc.24056 Xiaoyun Yan et al.
Points
- The study investigated the relationship between serum laminin (LN) levels and acute heart failure (AHF) prognosis in 199 patients.
- Patients were divided into event and non-event groups based on major adverse cardiovascular events (MACEs) during hospitalization.
- LN demonstrated a substantial predictive value for MACE occurrence (AUC: 0.8144) with a cutoff point of 77.9, high sensitivity (88.37%), and moderate specificity (58.33%).
- Multivariate analysis identified independent factors associated with MACEs, including increased LN levels, decreased ejection fraction, and lower diastolic blood pressure.
- Elevated LN levels were found to be independently correlated with poor prognosis in AHF patients, suggesting LN’s potential as a serological indicator for predicting MACEs in this population.
Summary
This research paper explored the relationship between serum laminin (LN) levels and the prognosis of acute heart failure (AHF). The study encompassed 199 AHF patients treated at Nantong First People’s Hospital from March 2019 to November 2021. These patients were categorized into two groups based on the occurrence of major adverse cardiovascular events (MACEs) during their hospital stay. Baseline data for all patients were gathered, and their LN levels were assessed. The research employed receiver operating characteristic (ROC) curve analysis to assess the predictive value of LN in identifying MACEs in AHF patients during their hospitalization. Additionally, multivariate logistic regression analysis was employed to identify independent factors associated with MACE occurrence in AHF patients.
Of the 199 AHF patients, 43 were classified in the event group, while 156 belonged to the non-event group. The ROC analysis revealed that LN exhibited a considerable predictive capacity for MACEs in AHF patients during hospitalization, with an area under the curve of 0.8144 and a 95% confidence interval of 0.7433–0.8855 (p < .0001). The determined cutoff point for LN was 77.9, with a specificity of 58.33% and a sensitivity of 88.37%. The multivariate logistic regression analysis highlighted several independent factors associated with MACE occurrence in AHF patients, including an increase in LN level (odds ratio [OR]: 1.020, 95% CI: 1.012–1.028), a decrease in ejection fraction (OR: 0.007, 95% CI: 0.000–0.362), and lower diastolic blood pressure (OR: 0.946, 95% CI: 0.913–0.981; p < .05).
In conclusion, this study found that elevated LN levels independently correlate with the occurrence of MACEs in AHF patients during hospitalization. These findings suggest that LN can serve as a serological indicator for predicting poor prognosis in individuals with AHF. This research sheds light on a promising avenue for enhancing the prognostic assessment of AHF patients, offering valuable insights for clinical practice.
Link to the article: https://onlinelibrary.wiley.com/doi/10.1002/clc.24056
References Yan, X., Ye, J., Chen, H., Jiang, Y., Xie, L., Zhang, Y., Qiang, W., Cai, H., Zheng, K., & Zhang, Q. (2023). Correlation between serum laminin level and prognosis of acute heart failure. Clinical Cardiology, 46(7), 818–822. https://doi.org/10.1002/clc.24056
