Article Impact Level: HIGH Data Quality: STRONG Summary of Clinical Cardiology, 46(8), 950–957. https://doi.org/10.1002/clc.24071 Dr. Ying Sun et al.
Points
- This study examines the predictive value of the CHA2DS2-VASc score for in-hospital major adverse cardiac events (MACEs) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary artery intervention.
- The CHA2DS2-VASc score is an independent predictor of MACEs as a continuous and category variable.
- Patients with higher CHA2DS2-VASc scores (2-3, 4-5, >5) have a significantly increased risk of MACEs compared to those with a score of 1.
- The predictive ability of the CHA2DS2-VASc score is more pronounced in male patients, while it does not show significant predictive value in female patients.
- Incorporating the CHA2DS2-VASc score into risk assessment models may help identify STEMI patients, particularly males, at a higher risk of experiencing adverse cardiac events during hospitalization. Further research is needed to understand the gender differences observed in the score’s predictive value.
Summary
This research paper investigates the predictive value of the CHA2DS2-VASc score for in-hospital major adverse cardiac events (MACEs) in patients with ST-elevation myocardial infarction (STEMI) who undergo primary percutaneous coronary artery intervention. The study included 746 STEMI patients divided into four groups based on their CHA2DS2-VASc scores. The aim was to assess the ability of the CHA2DS2-VASc score to predict in-hospital MACEs, with a specific focus on gender differences.
The study results showed that the CHA2DS2-VASc score was an independent predictor of MACEs when considered a continuous variable in a multivariate logistic regression analysis model. When analyzed as a category variable, the CHA2DS2-VASc score groups of 2-3, 4-5, and >5 were significantly associated with an increased risk of MACEs compared to the reference group with a score of 1. The predictive ability of the CHA2DS2-VASc score was particularly evident in male patients, while it did not show significant predictive value in female patients.
The study concludes that the CHA2DS2-VASc score could predict in-hospital MACEs in patients with STEMI, especially in males. The findings suggest incorporating the CHA2DS2-VASc score into risk assessment models may help identify patients at higher risk of adverse cardiac events during hospitalization. However, further research is needed to validate these results and explore the reasons behind the gender differences observed in the predictive value of the CHA2DS2-VASc score.
Link to the article: https://onlinelibrary.wiley.com/doi/10.1002/clc.24071
References Sun, Y., Ren, J., Wang, W., Wang, C., Li, L., & Yao, H. (2023). Predictive value of CHA 2 DS 2 ‐VASc score for in‐hospital prognosis of patients with acute ST‐segment elevation myocardial infarction undergoing primary PCI. Clinical Cardiology, 46(8), 950–957. https://doi.org/10.1002/clc.24071
