Article Impact Level: HIGH Data Quality: STRONG Summary of Clinical Cardiology, 46(6), 632–638. https://doi.org/10.1002/clc.24002 Hongling Wang et al.
Points
- Platelet-to-lymphocyte ratio (PLR) was evaluated as a potential biomarker for predicting the prognosis of acute myocardial infarction (AMI) patients.
- A total of 799 AMI patients who underwent successful primary percutaneous coronary intervention (PCI) within 12 hours of chest pain onset were included in the study.
- Patients with a high PLR (>178) had significantly higher rates of major adverse cardiac events (MACE), including heart rupture, acute heart failure, total adverse events, and mortality.
- Receiver operating characteristic curve analysis demonstrated that a PLR>178 accurately predicted adverse outcomes with 73% specificity and 65% sensitivity.
- Age, hypertension, and PLR were independent predictors of adverse outcomes, suggesting that PLR can be an independent risk factor for hospital-acquired complications in AMI patients.
Summary
This research paper aimed to evaluate the in-hospital outcomes of 799 acute myocardial infarction (AMI) patients who underwent successful primary percutaneous coronary intervention (PCI) within 12 hours of chest pain onset. The patients were divided into two groups based on the platelet-to-lymphocyte ratio (PLR): a low PLR group (n=511) and a high PLR group (n=288) using a PLR cutoff value of 178. Upon admission, the researchers assessed each patient’s total white blood cell count, neutrophil count, lymphocyte count, and platelet count.
The findings revealed that patients in the high PLR group with PLR>178 had a considerably greater incidence of major adverse cardiac events (MACE) than those in the low PLR group. Specifically, the high PLR group experienced higher rates of heart rupture, acute heart failure, total adverse events, and mortality due to all events. Receiver operating characteristic curve analysis demonstrated that a PLR>178 accurately predicted adverse outcomes with a specificity of 73% and a sensitivity of 65%. Additionally, multiple logistic regression analysis identified age, hypertension, and PLR as independent predictors of adverse outcomes.
The study concluded that AMI patients with a high PLR exhibited poor hospital outcomes. These findings suggest that PLR can be considered an independent risk factor for hospital-acquired complications, indicating that inflammation and a prothrombotic state may contribute to the unfavorable prognosis observed in high PLR patients. The research highlights the potential of PLR as a reliable and accessible criterion for risk stratification and categorization within the AMI patient population. Moreover, it contributes to the ongoing discussion regarding the predictive significance of PLR in the prognosis of individuals with coronary artery disease.
Link to the article: https://onlinelibrary.wiley.com/doi/10.1002/clc.24002
References Wang, H., Li, L., & Ma, Y. (2023). Platelet‐to‐lymphocyte ratio a potential prognosticator in acute myocardial infarction: A prospective longitudinal study. Clinical Cardiology, 46(6), 632–638. https://doi.org/10.1002/clc.24002
