Article Impact Level: HIGH Data Quality: STRONG Summary of Circulation, 0(0), 10.1161/CIRCULATIONAHA.122.060125. https://doi.org/10.1161/CIRCULATIONAHA.122.060125 Dr. Karl-Henrik Grinnemo et al
Points
- The main goal of the study was to find out the differences in pre-operative systolic and diastolic functioning among patients with tricuspid aortic valve (TAV) as well as a bicuspid aortic valve (BAV) who have serious isolated aortic stenosis (AS) and the prevalence of postoperative heart failure hospitalization and death.
- The results of this study indicated the significance of worse pre-operative left ventricular (LV) functioning with an escalated risk of postoperative hospitalization due to heart failure in patients with BAV with severe AS compared to those with TAV.
- Findings of this study also suggest that patients having BAV with severe AS can get benefit from earlier investigation and possibly earlier mediation.
Summary
Since now, the differences in adverse cardiac remodeling among patients with BAV and TAV with severe AS and its prognostic impact after the surgical aortic replacement have been unclear. So this study was designed to find out the differences in pre-operative systolic and diastolic functioning among patients with tricuspid aortic valve (TAV) as well as a bicuspid aortic valve (BAV) who have serious isolated aortic stenosis (AS) and the prevalence of postoperative heart failure hospitalization and death.
For this purpose, 271 patients were selected, from which there were 152 BAV patients and 119 TAV patients having severe isolated AS without any valvular heart disease or any other coronary artery disease, scheduled for aortic valve replacement surgery. A comprehensive assessment of pre-operative echocardiography of systolic and diastolic functioning of the left ventricular was performed. Heart failure events were noticed during prospective follow-up of 1260 days for BAV patients and 1441 days for TAV patients. The results of this study indicated the significance of worse pre-operative left ventricular (LV) functioning with an escalated risk of postoperative hospitalization due to heart failure in patients with BAV with severe AS compared to those with TAV. Findings of this study also suggest that patients having BAV with severe AS can get benefit from earlier investigation and possibly earlier mediation
Link to the article: https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.122.060125
References Wedin, J. O., Vedin, O., Rodin, S., Simonson, O. E., Hörnse Malmborg, J., Pallin, J., James, S. K., Flachskampf, F. A., Ståhle, E., & Grinnemo, K.-H. (n.d.). Patients with bicuspid aortic stenosis demonstrate adverse left ventricular remodeling and impaired cardiac function before surgery with increased risk of postoperative heart failure. Circulation, 0(0), 10.1161/CIRCULATIONAHA.122.060125. https://doi.org/10.1161/CIRCULATIONAHA.122.060125
