This study reveals how harnessing CD36-mediated endocytosis can improve the delivery of large and polar molecules, such as PROTACs, which previously struggled with cell membrane penetration. By optimizing drug binding to CD36...
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VISUALIZED: Machine Learning Model Predicts CAD Risk Using Genetics and Lifestyle Factors
Read further: Machine Learning Model Predicts CAD Risk Using Genetics and Lifestyle Factors
Intensive Blood Pressure Control Reduces Dementia Risk in Hypertensive Patients
This phase 3 trial found that intensive blood pressure control significantly reduced dementia risk in hypertensive individuals. With a target systolic BP of
ACE2 Supplementation with ACEIs/ARBs Enhances Blood Pressure Regulation in Hypertension
This study explores the benefits of ACE2 supplementation in hypertension treatment, particularly for patients with myxomatous mitral valve disease. When added to ACEIs or ARBs, ACE2 significantly improved blood pressure...
Long-Term Cardiovascular Effects of Hormone Therapy: LDL-C, HDL-C, and Insulin Resistance in Postmenopausal Women
This Women's Health Initiative study examined the long-term cardiovascular effects of hormone therapy (HT) in postmenopausal women. Both conjugated equine estrogens (CEE) alone and CEE+medroxyprogesterone acetate (MPA) improved...