New research challenges conventional views on atherosclerosis by revealing that plaques contain large, mutated cell clones, suggesting a surprising parallel between cardiovascular disease and tumor development.
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Structural Analysis Reveals Dynamic Four-State Complex in Paxillin-FAK Interaction
New research provides a detailed structural roadmap of the dynamic paxillin-FAK protein interaction, revealing a vulnerable four-state complex that offers a promising new target for precision cancer therapies.
Study Finds Foundational LLMs Highly Vulnerable to Health Disinformation Exploitation
A recent study reveals that leading AI models like GPT-4o can be easily manipulated into creating convincing and dangerous health disinformation, exposing critical vulnerabilities in their current safety features.
Distinct Transcriptional Pathways Regulate Inflammatory and Lysosomal Responses in Particle-Activated Macrophages
New research reveals that macrophage responses to pathogenic particles are governed by two independent signaling pathways. This finding could unlock novel therapies for inflammatory diseases like gout and silicosis.
CSF1R+ LAMM Cells Identified as a Key Mediator of CAR-T Therapy Resistance in B-Cell Lymphoma
New research uncovers how specific immune cells sabotage CAR-T therapy in B-cell lymphoma. Preclinical results show that a combination treatment could significantly improve patient survival by overcoming this resistance.