An investigation raises significant questions about the data integrity behind two key pharmacodynamic studies that supported the approval and decade-long use of the blockbuster antiplatelet drug ticagrelor.
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Efficacy of Extended CT Angiography for Cardioaortic Thrombus Detection in Acute Stroke
This randomized trial demonstrates that extending CT angiography to include the heart significantly improves the detection of cardioaortic thrombi in acute stroke patients without delaying time-sensitive emergency imaging...
Cannabis Use and Major Adverse Cardiovascular Events: A Meta-Analysis of Real-World Data
A significant new meta-analysis reveals cannabis use is linked to a doubled risk of cardiovascular death and significantly increased risks for acute coronary syndrome and stroke.
Somatic Mutations and Clonal Expansion Identified as Common Features of Atherosclerosis
New research challenges conventional views on atherosclerosis by revealing that plaques contain large, mutated cell clones, suggesting a surprising parallel between cardiovascular disease and tumor development.
Structural Analysis Reveals Dynamic Four-State Complex in Paxillin-FAK Interaction
New research provides a detailed structural roadmap of the dynamic paxillin-FAK protein interaction, revealing a vulnerable four-state complex that offers a promising new target for precision cancer therapies.