This research study aimed to investigate the impact of pulmonary valve replacement (PVR) on significant adverse clinical outcomes in patients with repaired tetralogy of Fallot (rTOF), a congenital heart defect. The study utilized...
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Impact of Statins on High-Risk Plaque Progression in Mild Coronary Artery Disease: Insights from CCTA
This research paper aims to assess the effect of statins on the progression of high-risk coronary atherosclerotic plaque (HRP) in mild coronary artery disease (CAD) and identify predictive factors for rapid plaque progression...
Enriching Gene-Edited Cells with CRaTER: Unveiling Cardiomyopathy-Associated Variants and Physiology
This research paper presents CRISPRa On-Target Editing Retrieval (CRaTER) as a novel approach to enrich cells with desired gene editing. The traditional method of generating transgenic cell lines involves screening numerous...
SoNIC: A Method for Isolating Single Cardiac Nuclei from Postmortem Tissue for Genomic Analysis
This research paper presents a novel SoNIC method for isolating single cardiac nuclei from human postmortem tissue to facilitate whole-genome amplification (WGA) and RNA sequencing (RNAseq). The authors emphasize the importance...
VISUALIZED: Indoxyl Sulfate-Mediated Mineralization of Valvular Interstitial Cells in Calcific Aortic Stenosis: Implications for Chronic Kidney Disease
Read further: Indoxyl Sulfate-Mediated Mineralization of Valvular Interstitial Cells in Calcific Aortic Stenosis: Implications for Chronic Kidney Disease