A ten-year analysis reveals a 23% increase in healthcare expenditures for cardiovascular-kidney-metabolic syndrome among U.S. young adults, driven largely by rising costs for heart failure and type 2 diabetes treatment.
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Long-Term Efficacy of Nucleoprotein-Targeted CCHF Replicon Particle Vaccine
Preclinical data indicates that a nucleoprotein-targeted replicon particle vaccine elicits durable antibody responses and significant protection against Crimean-Congo hemorrhagic fever for up to one year.
Oral Arginine Administration Suppresses Amyloid β Aggregation in AD Models
A preclinical study demonstrates that oral arginine administration suppresses amyloid β aggregation and alleviates neuroinflammation in animal models of Alzheimer's disease.
Noninvasive Nasal Delivery of STING Agonists for Aggressive Brain Tumor Treatment
A new intranasal nanomedicine utilizing spherical nucleic acids successfully activates the cGAS-STING pathway to inhibit glioblastoma growth and enhance checkpoint inhibitor efficacy.
Evaluation of Intensive Medical Therapy Alone versus Revascularization for Carotid Stenosis
The CREST-2 trial demonstrates that carotid stenting, unlike endarterectomy, significantly lowers stroke risk in patients with asymptomatic high-grade stenosis when added to intensive medical therapy.