Article Impact Level: HIGH Data Quality: STRONG Summary of Clinical Cardiology, 46(8), 899–905. https://doi.org/10.1002/clc.24086 Dr. Mingyang Yang et al.
Points
- Lipoprotein(a) (Lp[a]) has been recognized as a cardiovascular risk factor, but its association with atrial fibrillation (AF) has yielded inconsistent findings.
- A systematic review and meta-analysis examined nine relevant articles to assess the link between Lp(a) and new-onset AF.
- The study found no significant association between Lp(a) and AF; genetically elevated Lp(a) did not increase AF risk.
- Interestingly, different Lp(a) level stratifications led to varying results, with higher Lp(a) levels demonstrating an inverse association with AF risk.
- Additional research is necessary to uncover these findings’ mechanisms and better understand the potential inverse relationship between Lp(a) and AF.
Summary
In a systematic review and meta-analysis, the relationship between Lipoprotein(a) (Lp[a]) and atrial fibrillation (AF) was investigated, given the conflicting findings in previous studies. The research encompassed a thorough examination of health science databases, including PubMed, Embase, Cochrane Library, Web of Science, MEDLINE, and ScienceDirect, from their inception up to March 1, 2023, including nine relevant articles.
The analysis revealed no significant association between Lp(a) and new-onset AF (HR = 1.45, 95% confidence interval [CI]: 0.57–3.67, p = .432). Additionally, genetically elevated Lp(a) was not found to be linked to the risk of atrial fibrillation (OR = 1.00, 95% CI: 1.00–1.00, p = .461).
Interestingly, the study identified that different Lp(a) level stratifications yielded varying outcomes. Moreover, higher Lp(a) levels appeared to exhibit an inverse association with the risk of developing AF compared to individuals with lower Lp(a) levels. Consequently, Lp(a) levels were not significantly correlated with the incidence of AF. This research underscores the need for further investigation to elucidate the underlying mechanisms governing these results and to gain a more comprehensive understanding of Lp(a) stratification concerning AF, including the potential inverse relationship between Lp(a) and AF.
Link to the article: https://onlinelibrary.wiley.com/doi/10.1002/clc.24086
References Yang, M., Nasr, B., Liu, J., Du, Y., & Yang, J. (2023). The association between lipoprotein(A) and atrial fibrillation: A systemic review and meta‐analysis. Clinical Cardiology, 46(8), 899–905. https://doi.org/10.1002/clc.24086
