Article Impact Level: HIGH Data Quality: STRONG Summary of Clinical Cardiology, 47(4), e24259. https://doi.org/10.1002/clc.24259 Dr. Liping Dong et al.
Points
- A prospective cohort study of 158 maintenance hemodialysis (MHD) patients investigated the impact of interdialytic home blood pressure variability (BPV) on cardiac and all-cause mortality.
- Patients were categorized into tertiles based on systolic BPV (SBPV), and the study found a gradual increase in the risk of cardiac and all-cause death with higher SBPV tertiles.
- After adjusting for various covariates, Cox regression analysis revealed hazard ratios of 3.13 and 3.24 for all-cause mortality in Tertile 2 and Tertile 3, respectively, compared to Tertile 1.
- The findings indicated a positive correlation between increased interdialytic home SBPV and elevated mortality risk in patients with MHD, highlighting the potential prognostic significance of BPV in this patient population.
- The study’s results emphasize the clinical relevance of monitoring BPV in MHD patients and its implications for prognostic assessment and therapeutic strategies to reduce mortality risk in this population.
Summary
The research aimed to investigate the impact of interdialytic home blood pressure variability (BPV) on the prognosis of patients undergoing maintenance hemodialysis (MHD). A prospective cohort study comprising 158 MHD patients at the Wuhan Fourth Hospital hemodialysis unit was conducted to explore the association between systolic BPV (SBPV) and the primary endpoints of cardiac and all-cause mortality. Patients were categorized into tertiles based on SBPV, and Kaplan–Meier analysis was employed to assess the relationship between long-term survival and interdialytic home SBPV. Cox proportional hazards regression models were also utilized to identify risk factors contributing to poor prognosis.
The results demonstrated a gradual increase in the risk of cardiac death and all-cause death among patients categorized into tertiles of SBPV. Specifically, the hazard ratios for all-cause mortality in Tertile 2 and Tertile 3 were 3.13 and 3.24, respectively, compared to Tertile 1, after adjusting for various covariates. These findings underscored a positive correlation between elevated interdialytic home SBPV and heightened mortality risk in patients undergoing MHD, highlighting the potential prognostic significance of BPV in this patient population.
In conclusion, the study provided valuable insights into the association between interdialytic home SBPV and mortality risk in MHD patients. The findings emphasize the potential clinical relevance of monitoring BPV in this population and its implications for prognostic assessment and therapeutic strategies to reduce mortality risk in individuals undergoing maintenance hemodialysis.
Link to the article: https://onlinelibrary.wiley.com/doi/10.1002/clc.24259
References Dong, L., Tian, M., Li, H., Dong, J., & Song, X. (2024). Interdialytic home systolic blood pressure variability increases all-cause mortality in hemodialysis patients. Clinical Cardiology, 47(4), e24259. https://doi.org/10.1002/clc.24259
