Article Impact Level: HIGH Data Quality: STRONG Summary of Circulation, 147(1), 23–31. https://doi.org/10.1161/CIRCULATIONAHA.122.060667 Dr. Olli Raitakari et al
Points
- Young Finns and Bogalusa Heart survey respondents who were White were more likely to develop atherosclerotic cardiovascular disease if they had elevated lipoprotein levels in the future.
- The chance of getting an atherosclerotic cardiovascular outcome was four times higher in those with elevated lipoproteins and high-density lipoprotein cholesterol levels than in those without.
- These findings imply that measuring the presence of lipoproteins in young people may help identify those more susceptible to developing ASCVDs in the future.
Summary
The study’s primary objective was to determine whether the outcomes of atherosclerotic cardiovascular disease (ASCVD) in adults are associated with elevated lipoprotein levels in young people.
The current study includes two groups from the International Childhood Cardiovascular Cohort. For the current research, information from the YFS, which stands for Cardiovascular Risk in Young Finns Study, was utilized. ASCVD and carotid intima-media thickness in adults were linked to the number of lipoproteins in children ages 9 to 24. Links to national registries, such as the National Death Index and the Care Register for Health Care, allowed for identifying atherosclerotic cardiovascular results. Ninety-five patients who were part of this trial as of 2018 had been identified with more than one atherosclerotic cardiovascular incident. Data from the Bogalusa Heart Study for White individuals were used to replicate the results seen in the Finns Study.
By 2018, 95 members of the Young Finns cohort had been given a cardiovascular event diagnosis. The average age of the members was 48, and coronary artery disease was the most common disease. People with high lipoprotein levels in childhood, which were found to be 30 mg/dL, were more likely to develop ASCVDs as adults. During adolescence, the risk factors that were looked at were low-density lipoprotein cholesterol, body mass index, and smoking.
The researchers concluded that increased lipoprotein levels were linked to an increased risk of developing ASCVDs but not carotid intima-media thickness.
According to these findings, monitoring lipoprotein levels in young people might help identify those more likely to experience atherosclerotic cardiovascular problems as adults. Those with the highest risk for heart disease also had high levels of lipoprotein and low-density lipoprotein cholesterol, which are important things to point out. More research is needed to understand these correlations in various groups and the most effective preventative measures for such people.
Link to the article: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.060667
References Raitakari, O., Kartiosuo, N., Pahkala, K., Hutri-Kähönen, N., Bazzano, L. A., Chen, W., Urbina, E. M., Jacobs, D. R., Sinaiko, A., Steinberger, J., Burns, T., Daniels, S. R., Venn, A., Woo, J. G., Dwyer, T., Juonala, M., & Viikari, J. (2023). Lipoprotein(A) in youth and prediction of major cardiovascular outcomes in adulthood. Circulation, 147(1), 23–31. https://doi.org/10.1161/CIRCULATIONAHA.122.060667
