Article Impact Level: HIGH Data Quality: STRONG Summary of Clinical Cardiology, 46(5), 512–520. https://doi.org/10.1002/clc.24003 Dr. Cheng Yi et al.
Points
- Peripheral arterial disease (PAD) in coronary artery bypass grafting (CABG) patients was studied in relation to Lipoprotein(a) (LP(a)).
- One thousand one (1001) patients were divided into low and high LP(a) groups and PAD incidence was compared using ultrasound.
- PAD risk factors were identified as a history of diabetes mellitus (DM) and age, with gender influencing LP(a) serum levels.
- LP(a) levels ≥ 30 mg/dL were a significant risk factor for PAD in female patients while smoking history was a risk factor in males.
- Higher LP(a) levels were associated with more severe PAD in female patients without DM, indicating a gender deviation in LP(a)-PAD correlation.
Summary
This research paper aims to investigate the relationship between Lipoprotein(a) (LP(a)) and peripheral arterial disease (PAD) in patients undergoing coronary artery bypass grafting (CABG). A total of 1001 patients were divided into two groups based on their LP(a) levels: low LP(a) group (LP(a) < 30 mg/dL) and high LP(a) group (LP(a) ≥ 30 mg/dL). The incidence of PAD, diagnosed using ultrasound, was compared between the groups. Multivariate logistic regression analysis was performed, considering the influence of diabetes mellitus (DM) and gender on LP(a) serum levels.
The results revealed that a history of DM (odds ratio [OR] 2.330, p = .000 for males; OR 2.499, p = .002 for females) and age (OR 1.101, p = .000 for males; OR 1.071, p = .001 for females) were identified as risk factors for PAD. LP(a) levels ≥ 30 mg/dL were found to be a risk factor for PAD only in female patients (OR 2.589, p = .003) while smoking history was a risk factor only in male patients (OR 1.928, p = .000). Notably, LP(a) levels were not associated with the severity of PAD in DM patients of both genders. However, in female patients without DM, PAD was more severe in the high LP(a) group.
In conclusion, this study highlights that a history of DM and age are risk factors for PAD in CABG patients. Notably, a high level of LP(a) was found to be a significant risk factor only in female patients. Additionally, this research suggests a gender deviation in the correlation between LP(a) serum levels and the severity of PAD, as diagnosed by ultrasound. These findings contribute to our understanding of the association between LP(a) and PAD, emphasizing the need for gender-specific considerations in assessing PAD risk factors.
Link to the article: https://onlinelibrary.wiley.com/doi/10.1002/clc.24003
References Yi, C., Junyi, G., Fengju, L., Qing, Z., & Jie, C. (2023). Association between lipoprotein(A) and peripheral arterial disease in coronary artery bypass grafting patients. Clinical Cardiology, 46(5), 512–520. https://doi.org/10.1002/clc.24003
