Article Impact Level: HIGH Data Quality: STRONG Summary of Heart Rhythm, 20(3), 354–362. https://doi.org/10.1016/j.hrthm.2022.11.010 Dr. Lecia Dixen Wolder et al.
Points
- P terminal force V1 (PTFV1) is a marker of left atrial pathology associated with atrial fibrillation or flutter (AF).
- Abnormal PTFV1 was present in 44,549 subjects (16.7%) and was associated with an increased risk of AF and stroke/transient ischemic attack (TIA).
- Among patients with abnormal PTFV1, the highest tertile of PTDV1 and PTAV1 was linked to a higher risk of AF and stroke/TIA.
- The study population included 267,636 patients with a mean age of 49.2 years, and 53.4% were women.
- The results suggest that PTDV1 and PTAV1 can predict AF and stroke/TIA development.
Summary
In this study, abnormal PTFV1 was present in 44,549 subjects (16.7%) and was associated with an increased risk of AF and stroke/TIA. Cox regressions adjusted for age, sex, and relevant comorbidities were used to investigate the association between abnormal PTFV1 components and AF and stroke/TIA. The results showed that among patients with abnormal PTFV1, the highest tertile of PTDV1 (78–97 ms) was associated with a higher risk of AF (hazard ratio [HR] 1.37; 95% confidence interval [CI] 1.23–1.52) and a higher risk of stroke/TIA (HR 1.13; 95% CI 1.05–1.20). Similarly, for PTAV1, the highest tertile (78–126 μV) was linked to a higher risk of AF and stroke/TIA (HR 1.20; 95% CI 1.09–1.32 and HR 1.21; 95% CI 1.14–1.25, respectively).
The study population included 267,636 patients with a mean age of 49.2 years, and 53.4% were women. The patients were followed up for 6.5 years, during which 5803 had AF and 18,176 had stroke/TIA. The study used a large dataset from the Copenhagen General Practitioners Laboratory, which provided a unique opportunity to explore the association between PTFV1 components and the risk of AF and stroke/TIA.
In conclusion, the findings of this study indicate that abnormal PTFV1 is associated with an increased risk of AF and stroke/TIA. The results suggest that PTDV1 and PTAV1 can be used as predictors for AF and stroke/TIA development. The study highlights the importance of identifying patients with abnormal PTFV1, which could lead to earlier diagnosis and intervention to prevent the development of these conditions.
Link to the article: https://www.heartrhythmjournal.com/article/S1547-5271(22)02672-8/fulltext
References Wolder, L. D., Graff, C., Baadsgaard, K. H., Langgaard, M. L., Polcwiartek, C., Ji-Young Lee, C., Skov, M. W., Torp-Pedersen, C., Friedman, D. J., Atwater, B., Overvad, T. F., Nielsen, J. B., Hansen, S. M., Sogaard, P., & Kragholm, K. H. (2023). Electrocardiographic P terminal force in lead V1, its components, and the association with stroke and atrial fibrillation or flutter. Heart Rhythm, 20(3), 354–362. https://doi.org/10.1016/j.hrthm.2022.11.010
