Article Impact Level: HIGH Data Quality: STRONG Summary of Clinical Cardiology, 46(7), 721–728. https://doi.org/10.1002/clc.24035 Dr. Amirmohammad Khalaji et al.
Points
- Vasovagal syncope (VVS) is the most common type of syncope, and this research paper conducts a systematic review and meta-analysis to explore the relationship between VVS and vitamin D levels.
- The study, based on data from six relevant studies involving 954 cases, reveals a significant link between VVS and lower vitamin D serum levels, with VVS patients showing a standardized mean difference (SMD) of -1.05 (95% CI -1.54 to -0.57, p-value < .01) compared to non-VVS cases.
- Additionally, individuals with vitamin D deficiency have a substantially higher likelihood of experiencing VVS, as indicated by an odds ratio (OR) of 5.43 (95% CI 2.40 to 12.27, p-value < .01).
- The research underscores the clinical significance of monitoring vitamin D levels in VVS patients. It highlights the need for further randomized controlled trials to assess the potential impact of vitamin D supplementation in individuals with VVS.
- The study involved a comprehensive search across international databases. It employed rigorous meta-analysis techniques, ensuring a robust evaluation of the available data and emphasizing the importance of vitamin D in managing and understanding VVS.
Summary
This research paper presents a systematic review and meta-analysis investigating the potential correlation between vitamin D levels and vasovagal syncope (VVS), the most prevalent type of syncope. The study includes data extracted from six relevant studies, encompassing 954 cases. The meta-analysis revealed a significant association between VVS and lower vitamin D serum levels, with VVS patients exhibiting a standardized mean difference (SMD) of -1.05 (95% CI -1.54 to -0.57, p-value < .01) compared to non-VVS cases. Furthermore, individuals deficient in vitamin D showed a notably higher occurrence of VVS, indicated by an odds ratio (OR) of 5.43 (95% CI 2.40 to 12.27, p-value < .01). These findings emphasize the potential clinical relevance of monitoring vitamin D levels in VVS patients and suggest a need for further randomized controlled trials to evaluate the impact of vitamin D supplementation on VVS individuals.
The study involved a thorough search of international databases such as Scopus, Web of Science, PubMed, and Embase, utilizing specific keywords related to “vasovagal syncope” and “vitamin D.” The inclusion of diverse studies and rigorous meta-analysis techniques ensured a comprehensive evaluation of the available data. The association between vitamin D deficiency and VVS underscores the importance of considering vitamin D levels in managing and understanding this prevalent syncope type. The potential for vitamin D supplementation to impact VVS warrants further investigation through well-designed randomized controlled trials, offering potential avenues for enhanced clinical management strategies for individuals with VVS.
Link to the article: https://onlinelibrary.wiley.com/doi/10.1002/clc.24013
References Khalaji, A., Behnoush, A. H., & Tajdini, M. (2023). Association between vitamin D deficiency and vasovagal syncope: A systematic review and meta‐analysis. Clinical Cardiology, 46(7), 721–728. https://doi.org/10.1002/clc.24035
